Protein design of novel immunotherapeutic drugs

antibodies - gene therapy - vaccines - cellular therapies - peptides

Schoeder Lab

at Leipzig University, Medical Faculty, Institute for Drug Discovery

Our Research Interests

We use computational protein design including machine learning to design proteins with new functionalities. Through interchanging application of computational protein design and experimental validation, we design a new generation of protein drugs.  

News from the lab

Schoeder and Meiler Lab will be organizing the next European RosettaCon in Leipzig, 25th-27th September 2023 ( the date!
Congratulations, Moritz! Beautiful co-authorship with the Büning lab on how AAV can evade the innate immune response. Great collaboration on the design of AAVs!Check the paper out now in Molecular Therapy - Methods & Clinical Development
Link to the paper 
Out now in Curr. Opin. Struct. Biol.!
Hannes' paper about the entanglement of evolution, dynamics and entropy in GPCRs!

Congratulations, Hannes!
Link to his paper 
The Coalition for Epidemic Preparedness Innovations (CEPI) funds computational vaccine design for emerging viral diseases in the Schoeder and Meiler Lab!
With this funding we will use our computational methods to design stable viral surface proteins compatible with mRNA platforms. We will use Rosetta and machine learning in protein design to stabilize viral surface proteins. 
Press release of the University of Leipzig 
ScaDS.AI Associate membership!
Thank you ScaDS.AI for accepting my application for an associate membership! 
We are looking forward to develop the next generation of protein design algorithms with you! Discussion exicting questions in AI and machine learning will benefit our work greatly!
Link to the press release: 
Finally out in Structure!
Woods et al. on modeling and predicition of deletion mutants using AlphaFold2 and Rosetta benchmarked on a small helical domain. So far, deletion mutants were rarely structurally resolved, but here we have been using biomolecular NMR for an assigned helical SAM domain to observe structural changes for deletion mutants. 
A great project that was a lot of fun with Hope Woods at Vanderbilt University!
Link to the paper 
Summer School of the European Society of Gene and Cell Therapy (ESGCT)!
Vivian went for the Summer School of the ESGCT in France and had a great time. Thank you to the organizer for this incredible opportunity to get kick-started into gene and cell therapy research!
Thanks for the great Keystone conference on Computational Design and Modeling of Biomoleculesin Banff!
We enjoyed this conference very much, got to know the latest news in the protein design field and presented our own research. On the left site Johannes presenting his poster on de novo protein likeness and some impressions from the venue!
It is such a great time in computational protein design.
Congratulation to Johannes Klier for finishing his Master thesis! 
Amazing work trying to define what makes  de novo proteins so special and whether we can identify proteins with similar properties in nature. Johannes will stay on and pursue his PhD thesis with us. All the best for your studies!
Congratulation Moritz to your new co-authorship!
Amazing study with our collaboration partners Nadja Meumann and Hildegard Buening from Medical Hospital Hannover on liver-targeting AAV2s

Link to the paper: Meumann et al. 

Funding of the lab

We thank RosettaCommons, the state of Saxony, the Faculty of Medicine of Leipzig University,  the Coalition for Epidemic Preparedness Innovations (CEPI), the ScaDS.AI and the DAAD for their contributions to our research.

We are part of the SFB1423 "Structural Dynamics of GPCR Signaling". Check it out here: 



Leipzig University Medical FacultyInstitute for Drug DiscoveryLiebigstr. 19D-04103 Leipzig