Protein design of novel immunotherapeutic drugs
antibodies - gene therapy - vaccines - cellular therapies - peptides
Schoeder Lab
at Leipzig University, Medical Faculty, Institute for Drug Discovery
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Our Research Interests
We use computational protein design including machine learning to design proteins with new functionalities. Through interchanging application of computational protein design and experimental validation, we design a new generation of protein drugs.News from the lab!
Check below for some recent news from the lab.
Great having you in Leipzig, Hope and Rachel from RosettaCommons
Hope Woods and Rachel Clune from RosettaCommons visisted us in Leipzig to inform us about the work RosettaCommons does to provide protein design tools stable and well-documented. We learned about the valuable ressources they host. Afterwards, taking Hope and Rachel out to dinner!Congratulations to your publication, Jakob and Sophia!
Great collaboration with Denise Kühnert and Richard Daodu from the Robert-Koch-Institute, structurally modelling the LASV GPC and understanding a deletion.
Goodbye 2025 - Welcome 2026!The year ended with a great week of science with talks from Moritz Ertelt (Fraunhofer IPP, Munich, Germany) and Torben Schiffner (Scripps Research Institute, La Jolla, USA). Welcome 2026, new members, more sience!
A special adventure! Max and I were at the Latin American Workshop on AI for Protein Design! Thank you Cesar Ramirez-Sarmiento for inviting us to Puerto Varas in beautiful Chile! Max tought at the workshop and inspired to use our protein design tools. Thank you SECAI and EMBO for supporting this workshop - it was a truly amazing experience.
Special occasions call for special clothes!One highlight of the season was the state exams' ball hosted by the pharmacy students graduating in 2025! Perfect location with the Paulinum in the main building of Leipzig University. Getting out with the lab for some dancing and food. Congrats to our 2025 cohort and I wish our graduating pharmacy students all the best for their future career.
European RosettaCon 2025 in Ljubiljana, Slovenia!The Schoederlab was represented in high numbers by the team: Anna, Hannes, Christina, Dominic, Johannes, Sevilay, Max enjoyed European RosettaCon, meeting some new friends but also old ones.
Congratulations to Lars!Just started and already the first paper out. A review together with our collaboration partners Cecile Scholl and Sascha Laubinger in the SNP2PROT CRC on the structural determinants of pri-miRNA precessing of DCL-1!Link to the publication
What a day! First Lab graduee! Congratulations to Dr. Moritz Ertelt on the successful defense of his thesis. Moritz has published at least three first author papers and many more co-authors - he has inspired the whole lab to explore AI in protein design. Today this journay ends with the succesful defense of his thesis in Leipzig. On the pictures, you also see Dr. Fabian Ließmann (Meiler Lab), CEO of AI-DT, who also succesfully defended his thesis on the same day. Congratulations! And all the best with your future careers.
2nd Pharmacy Science Day in Leipzig.Today, Diploma and Master students presented the results from their thesis work, while PhD stduents gave introductions to their topcis. For the Schoeder Lab, Leonie Adam presented on her master thesis on mammalian display for the LASV glycoprotein (mentor Dr. Sophia Peter) and Anna Nobis, a PhD student, showed results from her work on the design of paramyxovirus vaccines.
Lab retreat to Pockau-Lengefeld! We enjoyed three days of science in the Strobelmühle. Also: finally a new group picture!
Congratulations Lorenz on your paper!Lorenz went through picking a target (not an easy one), establishing a test system, running a screen and synthesizing compounds all by himself. Great work! Here is the link
GfV 2025 in Hamburg!Sophia, Roman, Franz, Corinna and Jakob presented our research on stabilizing viral glycoproteins!Fantastic meeting with uncharacteristically nice weather in Hamburg.
Moritz' paper on AI-Rosetta integration and comparing AI protein design tools is out in Science Adavances!Great to see this story being out there. Briefly, what Moritz shows is that AI tools outperform traditional biophysical methods such as Rosetta by omitting deleterious mutations during design. Interestingly, the predictive power for the "scoring problem" - the ability to differentiate between designs and rank them is poor for AI models. It is advisable to use an alternative method for it. Link to the publication
Congratulations, Victoria, on the co-authorship in Zeides et al. in Nature Communications !
This is our first venture into enzyme design - expanding the substrate scope of the VHPOs from the Gulder lab. Great collaboration! Victoria used ProteinMPNN to study which mutations could be designed in the second shell of this enyzme. Check it out here: Link to the publication
This is our first venture into enzyme design - expanding the substrate scope of the VHPOs from the Gulder lab. Great collaboration! Victoria used ProteinMPNN to study which mutations could be designed in the second shell of this enyzme. Check it out here: Link to the publication
Congratulations, Johanna and Max to the first paper in 2025 in Cancer Communications!
Johanna and Max expressed proteins found in multiple melanoma tissue through single-cell transcriptomics and evaluated them in protein-protein binding assays. Great collaboration with Manfred Kunz from the Dematology Department of Leipzig University.
Link to the publication
Johanna and Max expressed proteins found in multiple melanoma tissue through single-cell transcriptomics and evaluated them in protein-protein binding assays. Great collaboration with Manfred Kunz from the Dematology Department of Leipzig University.
Link to the publication
Congratulations, Vivian and Moritz!Great to see the work of our collaboartion partners Markus Barden and Hinrich Abken out in J. Immunother. Cancer.
We studied the tonic signaling and binding properties of a series of HER2-binding CAR T cells. Vivian and Moritz focused on the scFv's and charakterized their biophysical properties.
Link to the publication
We studied the tonic signaling and binding properties of a series of HER2-binding CAR T cells. Vivian and Moritz focused on the scFv's and charakterized their biophysical properties.
Link to the publication
Goodbye, Guz! It was wonderful to host you for the past three month. Hope you enjoyed Leipzig and our science.
This is the farewell dinner at Leipzig's Moritzbastei.
This is the farewell dinner at Leipzig's Moritzbastei.
EuropeanRosettaCon 2024 in Copenhagen!
Great Meeting and great science. Jakob, Johannes, Sevilay, (Anna, Moritz, Hannes) and Dominik presenting their posters. I had the chance to talk some vaccine design.
Thank you to our funding agencies to make this possible: SECAI, ScaDS.AI, CEPI, SFB1423, DEN.BI and Rosetta Commons.
Looking forward to the 4th European RosettaCon in Slovenia.
Great Meeting and great science. Jakob, Johannes, Sevilay, (Anna, Moritz, Hannes) and Dominik presenting their posters. I had the chance to talk some vaccine design.
Thank you to our funding agencies to make this possible: SECAI, ScaDS.AI, CEPI, SFB1423, DEN.BI and Rosetta Commons.
Looking forward to the 4th European RosettaCon in Slovenia.
Congratualtions, Franz, on winning the Diploma prize of the Chamber of Pharmacists of Saxony. Franz was awarded this prize because of his excellent diploma thesis on the design of new SARS-CoV-2 vaccine candidates but also for his engagement in the student councal during his studies.
Franz is a PhD student in the Schoeder lab now, focussing on vaccine design for pandemic preparadness. Happy (and proud) to have you in the lab!
Franz is a PhD student in the Schoeder lab now, focussing on vaccine design for pandemic preparadness. Happy (and proud) to have you in the lab!
Disease X project Meeting in Chicago - discussing science with our collaboration partners.
Wonderful to re-connect and discuss our progress.
Wonderful to re-connect and discuss our progress.
SaxoCell - the Saxonian Cluster for Future was prolonged for a second funding period! We are part of this exciting team now and look forward to working with the partners for novel CAR T cell and CAR NK cell therapies.
If you want to read more about SaxoCell, click here.
If you want to read more about SaxoCell, click here.
Johanna and Vivian presented our work on the design of CAR T cell antigen recognition domains at the 7th European Congress of Immunology in Dublin! Looks like great science and fun!
The SNP2Prot Collaborative Research Center 1664 lead my Marcel Quint from University of Halle was funded by the German Research Foundation. We are excited to work with this exciting team. Looking forward to designing protein together with my project partner Sascha Laubinger to target the Dicer-like-1 protein in Arabidopsis thaliana.
Link to the homepage of SNP2PROT
Link to the homepage of SNP2PROT
Great team effort! And congratulations to Sophia on her review on arenavirus being accepted in Incet. Genet. Evol.Link to the publication
Wonderful conferences this spring in Vienna and Hannover!
Sophia, Tom and I presented our vaccine work at the GfV 2024 in Vienna and showed our recent succes in designing vaccines.
Dieter, Sophia and I went to visit the Keystone HIV and (Re-) emerging viruses in Hannover two weeks later. Great talks - and catching up in the vaccine field!
Sophia, Tom and I presented our vaccine work at the GfV 2024 in Vienna and showed our recent succes in designing vaccines.
Dieter, Sophia and I went to visit the Keystone HIV and (Re-) emerging viruses in Hannover two weeks later. Great talks - and catching up in the vaccine field!
Using the Evolutionary Scale Model (ESM) together with biopysical modeling in Rosetta. Now possible as we show in our most recent work in ACS Synthetic Biology!
Congratulations to Moritz for this amazing work!
Link to the publication
Congratulations to Moritz for this amazing work!
Link to the publication
Congratulations Johanna!
Our work on assigning the protein backbone chemical shifts for mouse siderocalin in 3D biomolecular NMR experiments was accepted in Biomol. NMR Assign.! A big thanks to Max Kade Foundation for being the sponsor on Johanna's research stay at Vanderbilt University.
Link to the publication
Our work on assigning the protein backbone chemical shifts for mouse siderocalin in 3D biomolecular NMR experiments was accepted in Biomol. NMR Assign.! A big thanks to Max Kade Foundation for being the sponsor on Johanna's research stay at Vanderbilt University.
Link to the publication
Out now in PLoS Comp. Bio! Design of post-translational predictions (PTMs) using machine learning in Rosetta.
Moritz' new paper on the integration of machine learning models for PTM prediction is out now in PLoS Comp. Bio. It covers 19 possible PTMs to design.
Go design your favorite PTM:Link to the publication
Moritz' new paper on the integration of machine learning models for PTM prediction is out now in PLoS Comp. Bio. It covers 19 possible PTMs to design.
Go design your favorite PTM:Link to the publication
Funding of the lab
We thank RosettaCommons, the state of Saxony, the Faculty of Medicine of Leipzig University, the Coalition for Epidemic Preparedness Innovations (CEPI), the ScaDS.AI and the DAAD for their contributions to our research.
We are part of the SFB1423 "Structural Dynamics of GPCR Signaling". Check it out here: research.uni-leipzig.de/sfb1423/
We are also part of SFB1664 "SNP2PROT - Plant Proteoform Diversity". Link to SNP2PROT
Contact
Contact
clara.schoeder[at]medizin.uni-leipzig.de
Leipzig University Medical FacultyInstitute for Drug DiscoveryLiebigstr. 19D-04103 LeipzigPage updated
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