Protein design of novel immunotherapeutic drugs
antibodies - gene therapy - vaccines - cellular therapies - peptides
at Leipzig University, Medical Faculty, Institute for Drug Discovery
Our Research InterestsWe use computational protein design including machine learning to design proteins with new functionalities. Through interchanging application of computational protein design and experimental validation, we design a new generation of protein drugs.
News from the lab
Max, Johannes and Hannes joined me in visiting this outstanding meeting in a fantastic location. Just a train ride away in beautiful Prague.
We discussed the current state of bioinformatics and explored a lot of new ressources.
Thanks for the organizers for inviting me to speak about our protein design ideas!
Vivian and Johanna presented their work in a fantastic venue and explored new trends in gene and cell therapy. Johanna showed a poster on her work on scTv's - computationally deisgn and experimentally tested in our lab (cudos to Max Lingner and Victoria Most for helping with the project).
Vivian presented her work on profiling the AAV2 humoral immune response and her quest to reliable B cell sorting for AAV2 positive cells.
All the best wishes for your PhD studies!
Schoeder and Meiler Lab organized European RosettaCon in Leipzig, 25th-27th September 2023 (https://europeanrosettacon.org/)
We thank the wonderful speakers for the great science: Charlotte Deane from Oxford University, Andrew Ward from Scripps Research, Roland Dunbrack from Philadelphia, Jeffrey J. Gray from Johns Hopkins, Bill Schief from Scripps Research, Tanja Kortemme from UCSF, Eric S. Fischer from Dana-Faber-Institute and many more.
Special thanks go to my incredible team that helped with everything, especially Birke und Christina, and Christa Kühnelt from the Pharmecuetical Chemistry, Lukas von Bredow from the Tretbar/Meiler labs and the team of the Destille for hosting us!
Link to the paper
With this funding we will use our computational methods to design stable viral surface proteins compatible with mRNA platforms. We will use Rosetta and machine learning in protein design to stabilize viral surface proteins.
Press release of the University of Leipzig
Thank you ScaDS.AI for accepting my application for an associate membership!
We are looking forward to develop the next generation of protein design algorithms with you! Discussion exicting questions in AI and machine learning will benefit our work greatly!
Link to the press release:
Woods et al. on modeling and predicition of deletion mutants using AlphaFold2 and Rosetta benchmarked on a small helical domain. So far, deletion mutants were rarely structurally resolved, but here we have been using biomolecular NMR for an assigned helical SAM domain to observe structural changes for deletion mutants.
A great project that was a lot of fun with Hope Woods at Vanderbilt University!
Link to the paper
Vivian went for the Summer School of the ESGCT in France and had a great time. Thank you to the organizer for this incredible opportunity to get kick-started into gene and cell therapy research!
We enjoyed this conference very much, got to know the latest news in the protein design field and presented our own research. On the left site Johannes presenting his poster on de novo protein likeness and some impressions from the venue!
It is such a great time in computational protein design.
Amazing work trying to define what makes de novo proteins so special and whether we can identify proteins with similar properties in nature. Johannes will stay on and pursue his PhD thesis with us. All the best for your studies!
Amazing study with our collaboration partners Nadja Meumann and Hildegard Buening from Medical Hospital Hannover on liver-targeting AAV2s
Link to the paper: Meumann et al.
Funding of the lab
We thank RosettaCommons, the state of Saxony, the Faculty of Medicine of Leipzig University, the Coalition for Epidemic Preparedness Innovations (CEPI), the ScaDS.AI and the DAAD for their contributions to our research.
We are part of the SFB1423 "Structural Dynamics of GPCR Signaling". Check it out here: research.uni-leipzig.de/sfb1423/
clara.schoeder[at]medizin.uni-leipzig.deLeipzig University Medical FacultyInstitute for Drug DiscoveryLiebigstr. 19D-04103 Leipzig